World Health Organization predicts daibetes to rank 7^th among global mortality causes by 2030. As per NEWSTRAITSTIMES  reports one out of every five above the age of 30 suffer from diabetes in Malaysia and an estimated prediction unfolds 4.5 million diabetics in Malaysia above the age of 18 by 2020.  Current antidiabetic drugs suffer from serious side effects and plant-based green bioactives provide a useful alternative. Plant bioactive silymarin is reported to be beneficial both type 1 and type 2 diabetes. The compound however is constrained due to solubility and bioavailabilty limitations and nanomedicine design was construed as the probabale answer. Oral treatment with Sm nanomedicines had a marked restorative effect on streptozotocin induced diabetic rats as evident from biochemical and histological observations. Nanomedicines evaluated  show sufficient promise to emerge as patient friendly alternative therapeutics in management of diabetes.